About

This is a discussion-oriented meeting and the formats of both the symposium and workshop are designed to allow ample time for stimulating discussions focused on understanding the current state of the art, knowledge gaps, and unanswered questions in the field. The ultimate goal is to achieve some convergence on defining the research priorities and opportunities that would enable us to translate our understanding of alpha-synuclein functions in health and disease to accelerate ongoing and future efforts aimed at developing effective therapies for the treatment of Parkinson’s disease and related synucleinopathies.

The first two days will consist of a series of well-structured sessions focused on critical assessment of :

  • Our current understanding of the normal functions of alpha-synuclein.
  • The short- and long-term consequences of modulating alpha-synuclein levels.
  • The role of aggregation-independent alpha-synuclein toxicity mechanisms.

On the third day, we will have a workshop that will consist of four-round table discussions which will reflect on the presentations and discussions from the symposium and focusing on :

  • Reassessing the interplay between alpha-synuclein normal functions and its role in the pathogenesis of PD and other synucleinopathies.
  • Implications of understanding Alpha-synuclein functions and regulating its levels for the development of prevention and disease modifying strategies.
  • Challenges and opportunities for the next five years.
  • New models for collaborations and consortia, including between industry-academia, to advance translational research in Parkinson’s disease. 

Confirmed speakers

Robert Edwards
USA

University of California San Francisco

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Robert Edwards
USA
Hilal A. Lashuel
Switzerland

École polytechnique fédérale de Lausanne

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Hilal A. Lashuel
Switzerland
John Trojanowski
USA

University of Pennsylvania

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John Trojanowski
USA
Vladimir Buchman
UK

Cardiff university

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Vladimir Buchman
UK
Poul Jensen
Denmark

Aarhus University

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Poul Jensen
Denmark
Michael Zasloff
USA

Georgetown University

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Michael Zasloff
USA
Jon Stamford
UK

Co-founder of Parkinson's Movement

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Jon Stamford
UK
David Sulzer
USA

Columbia University

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David Sulzer
USA
David Brown
UK

University of Bath

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David Brown
UK
Sreeganga Chandra
USA

Yale University

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Sreeganga Chandra
USA
Sarah Shahmoradian
Switzerland

Paul Scherrer Institute

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Sarah Shahmoradian
Switzerland
Dimitri Krainc
USA

Northwestern University

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Dimitri Krainc
USA
Michael Lee
USA

University of Minnesota

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Michael Lee
USA
David Ashford-Jones
UK

WellumPhoenix co-founder

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David Ashford-Jones
UK
Peter Lansbury
USA

Harvard University

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Peter Lansbury
USA
Virginia Lee
USA

University of Pennsylvania

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Virginia Lee
USA
Gabriele Kaminski
UK

University of Cambridge

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Gabriele Kaminski
UK
David Eliezer
USA

Cornell University

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David Eliezer
USA
Henning Stahlberg
Switzerland

University of Basel

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Henning Stahlberg
Switzerland
Brian Fiske
USA

Michael J. Fox., NY, USA

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Brian Fiske
USA
Isabel Fariñas
Spain

University of Valencia

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Isabel Fariñas
Spain
Maria Grazia Spillantini
UK

University of Cambridge

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Maria Grazia Spillantini
UK
Vladan Lucic
Germany

Max Planck Institute of Biochemistry

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Vladan Lucic
Germany
Michael Schlossmacher
Canada

University of Ottawa

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Michael Schlossmacher
Canada
Serge Przedborski
USA

Columbia University

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Serge Przedborski
USA
Benjamin Stecher
Canada

Founder of tmrwedition.com

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Benjamin Stecher
Canada

Guest panelists

Donato Di Monte
Germany

German center for neurodegenerative diseases, Bonn

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Donato Di Monte
Germany
Pekka Kallunki
Denmark

Lundbeck

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Pekka Kallunki
Denmark
Warren Hirst
USA

Biogen

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Warren Hirst
USA
Martin Citron
Belgium

UCB Pharma, Brussels area

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Martin Citron
Belgium
Jan Stoehr
Switzerland

AC Immune SA

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Jan Stoehr
Switzerland
Marco Giorgetti
Germany

AbbVie Neuroscience Discovery

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Marco Giorgetti
Germany
Kalpana Merchant
USA

Chaperone Therapeutics, Portland

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Kalpana Merchant
USA
Gergana Galabova
Austria

AFFiRiS AG

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Gergana Galabova
Austria
Markus Britschgi
Switzerland

Roche, Basel area

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Markus Britschgi
Switzerland
Peggy Taylor
USA

BioLegend

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Peggy Taylor
USA

Organizing committee

Hilal A. Lashuel
Switzerland

École polytechnique fédérale de Lausanne

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Hilal A. Lashuel
Switzerland
Tiago Outeiro
Germany

University Medical Center Goettingen

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Tiago Outeiro
Germany
Leonidas Stefanis
Greece

Foundation of the Academy of Athens
University of Athens

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Leonidas Stefanis
Greece
Abid Oueslati
Canada

Laval University

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Abid Oueslati
Canada
Kalpana Merchant
USA

Chaperone Therapeutics, Portland

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Kalpana Merchant
USA
Philipp Kahle
Germany

University of Tübingen

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Philipp Kahle
Germany
Markus Britschgi
Switzerland

Roche, Basel area

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Markus Britschgi
Switzerland
Anne-Laure Mahul-Mellier
Switzerland

École polytechnique fédérale de Lausanne

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Anne-Laure Mahul-Mellier
Switzerland

Program

PHD – Postdoc Summit

This session will consist of brief presentations by the students and post-docs followed by 1 hour of discussion to capture their views, insights, and perspectives on the unanswered questions and research priorities. The students and post-docs will be given the opportunity to moderate one of the round table discussion on Day 3.

Morning session : Location EPFL, building CM, Auditorium CM 1 1 – 08:45 – 12:00

Session chairs: Hilal Lashuel and Amberley Stephens

08:45 - 09:00

CM 1 1
Antoni Kowalski

Aarhus University - Denmark

Gaia Faustini

University of Brescia - Italia

Ricardo Guerrero-Ferreira

C-CINA. University of Basel - Switzerland

09:40 – 10:00

Enjoy a break in a relaxed atmosphere

Ludivine Breger

Institut Maladies Neurodegeneratives - France

11:00 – 11:20

Enjoy a break in a relaxed atmosphere

• Unanswered questions
• Unquestioned answers/dogmas
• Challenges and opportunities
• Research priorities

Lunch Break: Lunch for the speakers – SV cafeteria – Lashuel’s team – 12:05 – 12:45

Afternoon sessions : Starling conference center – 13:00 – 19:30

13:00 – 13:15

By : Hilal Lashuel and Benjamin Stecher

Robert Edwards

The Function of Synuclein

Session 1 : Structural aspects – 14:00 – 17:40

Session chairs: Maria Spillantini and Robert Edwards

Sreeganga S Chandra

Yale University - USA

David Eliezer

Cornell University - USA

14:50 - 15:10

Enjoy a hot drink in a relaxed atmosphere.

Gabriele Kaminski

University of Cambridge - United Kingdom

Vladan Lucic

Max Planck Institute of Biochemistry - Germany

Isabel Farinas

University of Valencia - Spain

17:15 – 17:40

Enjoy a hot drink in a relaxed atmosphere.

Session 2 : Regulation of α-synuclein – 17:40 – 19:30

Session chairs: Tiago Outeiro and Warren Hirst

Poul Jensen

Aarhus University - Denmark

Q/A and panel discussion with all the speakers

Dinner : 20:00 – 22:00

20:00 – 22:00

Gina

Morning sessions : Starling conference center – 08:30 -12:35

Session 1 – Specific subcellular roles of α-synuclein – 08:30 -10:15

Session chairs: Leonidas Stefanis and Philipp Khale

Serge Przedborski

Columbia University - USA

Dimitri Krainc

Northwestern University - USA

Tiago Outeiro

University Medical Center Goettingen

09:45 – 10:10

Q/A and panel discussion with all the speakers

10:10 - 10:35

Enjoy a hot drink in a relaxed atmosphere.

Session 2 – α-synuclein and the immune system – 10:15 -12:35

Session chairs: Kalpana Merchant and Poul Henning Jensen

David Sulzer

Columbia University - USA

Michael Zasloff

Georgetown University- USA

David Brown

University of Bath - UK

Markus Britschgi

Roche, Basel area - Switzerland

12:15 – 13:00

Q/A and panel discussion with all the speakers

Lunch break: 13:00 – 14:00

12:35 – 14:00

Lunch

Afternoon sessions : Starling conference center – 14:00 -17:45

Session 3 – α-synuclein and brain pathology (1) – 14:00 -15:35

Session chairs: Markus Britschgi and Marco Giorgetti

14:50 – 15:15

Q/A and panel discussion with all the speakers

15:15 – 15:35

Enjoy a hot drink in a relaxed atmosphere.

Session 4 – α-synuclein and brain pathology (2) – 15:35 -17:45

Session chairs: John Trojanowski and David Eliezer

Henning Stahlberg

University of Basel - Switzerland

Q/A and panel discussion with all the speakers

Boat tour + dinner: 17:45 – 21h45

Desparture from the Starling hotel

17:45 – 21:45

Morning sessions: Starling conference center – 09:00 – 12:40

Session 1: Pathological roles of α-synuclein – 09:00 -11:40

Session chairs: Michael Lee and Martin Citron

Hilal Lashuel

École polytechnique fédérale de Lausanne - Switzerland

Panel discussion: α-synuclein pathology spreading

11:15 - 11:40

Enjoy a hot drink in a relaxed atmosphere.

Session 2: PhD students/Post-doc led panel – 11:40 – 12:40

Moderators: Anne-Laure Mahul-Mellier, Johannes Burtscher, Siv Vingill, Amberley Stephens

PhD students/Post-doc led Panel

Lunch break: 12:40 – 14:20

12:40 – 14:20

PhD students/Post-doc led Panel

Afternoon sessions: Starling conference center – 14:20 – 17:20

Kalpana Merchant
α-synuclein targeted therapies: opportunities and challenges

Moderator: Kalpana Merchant

Panel:
• Donato Di Monte – German Center for neurodegenerative diseases, Germany
• Martin Citron – UCB, Belgium
• Markus Britschgi – Roche, Switzerland
• Pekka Kallunki – Lundbeck, Denmark
• Andreas Muhs – AC immune, Switzerland
• Gergana Galabova – Affiris AG, Austria
• Peggy Taylor – BioLegend, USA
• Warren Hirst – Biogen, USA
• Marco Giorgetti – Abbvie, Neuroscience Discovery, Germany
• Hugo Vanderstichele, Adx neurosciences

Brian Fiske

Moderator: Brian Fiske

Panel :
• Dr. Jon Stamford
• David Ashford-Jones
• Benjamin Stecher

17:00 – 17:20

Our sponsors

Feedback – Testimonies

Photos

All the following pictures belong to the Lashuel Laboratory. Please e-mail marie.rodriguez@epfl.ch for any particular use

Event location

Here, you will find directions to the conference venue. More space to meet and network!

VISIT US

SV-BMI-LMNN
AI 2.151 - Station 19
CH-1015 Lausanne, Switzerland

EMAIL US

marie.rodriguez@epfl.ch

CALL US

+41 21 693 07 92